L-Lysine monohydrochloride → (2S)-2-amino-6-(((tert-butoxy)carbonyl)amino)hexanoic acid

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A solution of L-lysine monohydrochloride (20.0 g, 109.5 mmol) and benzotriazole (14.3 g, 120.0 mmol) in a mixture of water (66.6 mL) and THF (111.0 mL) at pH 12 was treated with t-butyl phenyl carbonate (24.3 mL, 131.4 mmol) and stirred 18 hours at 60° C. The mixture, initially 2 layers, became a clear orange solution and the product was approximately 75% (NMR).

Herkunft & Nachweise