HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 913407Erstellt: 26. Oktober 2026
Cesium carbonate → 2-[4-Chloro-5-cyano-2-(difluoromethyl)-1H-indol-1-yl]propanamide
https://huagongshe.com/reaction/913407
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | 2-Bromopropanamide | HCID 101118 | — |
| Edukt | 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile | HCID 24985632 | — |
| Produkt | 2-[4-Chloro-5-cyano-2-(difluoromethyl)-1H-indol-1-yl]propanamide | HCID 24985805 | — |
Reaktionsschritte
Synthesized as described in Example 4 using 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile, 2-bromo-propionamide (2 eq) and Cs2CO3 (2 eq). After heating at 90° C. for 4 h, additional 2-bromo-propionamide (2 eq) and Cs2CO3 (2 eq) were added and the reaction mixture heated at 110° C. for 15 h: MS (ES) m/z 298 (M+1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08026262B2 |
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| Quelldatensatz | uspto-grants-2011_09 |
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| ORD ID | ord-615baa6b5e3d4f3482bd33eadea97978 |
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| Quellennotiz | uspto-grants-2011_09 |
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