Methanol → HCID 67399122, Verbindung
Reaktionsgleichung
[NH:1]([C:8](=O)[CH2:9][C:10]1[N:11]=[C:12]([S:15][C:16]([CH3:21])([CH3:20])[C:17]([OH:19])=[O:18])[S:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO>O1CCCC1>[NH:1]([CH2:8][CH2:9][C:10]1[N:11]=[C:12]([S:15][C:16]([CH3:21])([CH3:20])[C:17]([OH:19])=[O:18])[S:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a suspension of 2-{[4-(2-anilino-2-oxoethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid resin (2.9 g) obtained in Example 488-1 in tetrahydrofuran (30 mL) was added 1 mol/L borane-tetrahydrofuran complex (24 ml), and the mixture was stirred at room temperature overnight. Methanol was gradually added to the reaction mixture, and the mixture was stirred at room temperature overnight. The resin was collected by filtration, washed three times with methanol, and vacuum dried to give the title pale-brown resin (2.4 g).