Diisopropylcarbodiimide → HCID 67399332, Verbindung

An operation similar to that of Example 461-5 was performed 3 times using 2-{[4-(carboxymethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid resin obtained in Example 461-4 and 4-aminophenylacetic acid ethyl ester. To a suspension of the obtained resin in dimethylformamide (30 mL) were added HOBT monohydrate (0.92 g), diisopropylcarbodiimide (0.93 ml) and 4-aminophenylacetic acid ethyl ester (1.1 g), and the mixture was stirred at room temperature overnight. The resin was collected by filtration from the reaction mixture, washed once each with dimethylformamide and methanol, twice with dimethylformamide, once with methanol, three times with tetrahydrofuran and finally once with methanol, and vacuum dried to give the title pale-brown resin (3.1 g).

1. filtrationThe resin was collected by filtration from the reaction mixture
2. washwashed once each with dimethylformamide and methanol
3. dry with materialtwice with dimethylformamide, once with methanol, three times with tetrahydrofuran and finally once with methanol, and vacuum dried

ORD-Eintrag

ord-aec8cd0ab72c44d6b6d7286d819de817

Quelldatensatz

uspto-grants-2011_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08026370B2