Trifluoroacetic acid → HCID 59759220, Verbindung
Reaktionsgleichung
[C:1]([CH2:4][C:5]1[N:6]=[C:7]([S:10][C:11]([CH3:16])([CH3:15])[C:12]([OH:14])=[O:13])[S:8][CH:9]=1)(O)=O.[NH2:17][C:18]1[CH:19]=[C:20]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:21]=[CH:22][CH:23]=1.FC(F)(F)C(O)=O>>[C:20]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:21]=[CH:22][CH:23]=[C:18]([NH:17][CH2:1][CH2:4][C:5]2[N:6]=[C:7]([S:10][C:11]([CH3:16])([CH3:15])[C:12]([OH:14])=[O:13])[S:8][CH:9]=2)[CH:19]=1Komponenten
4
Versuchsvorschrift
Operations similar to Example 520-1 and Example 488-2 were performed using 2-{[4-(carboxymethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid resin synthesized in Example 461-4 and 3-aminobiphenyl as starting materials. To the obtained resin was added trifluoroacetic acid and the mixture was left standing overnight. The resin was filtered off and the filtrate was concentrated by blowing nitrogen gas thereto, and purified by preparative HPLC to give the title compound (0.015 g) as a pale-brown oil.