HCID 67399201, Verbindung → HCID 67396216, Verbindung
Reaktionsgleichung
[C:1]([CH2:4][C:5]1[N:6]=[C:7]([S:10][C:11]([CH3:16])([CH3:15])[C:12]([OH:14])=[O:13])[S:8][CH:9]=1)(O)=[O:2]>O1CCCC1>[OH:2][CH2:1][CH2:4][C:5]1[N:6]=[C:7]([S:10][C:11]([CH3:16])([CH3:15])[C:12]([OH:14])=[O:13])[S:8][CH:9]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a suspension of 2-{[4-(carboxymethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid resin (10 g) synthesized in Example 461-4 in tetrahydrofuran (50 mL) was added 1 mol/L borane-tetrahydrofuran complex (25 ml) under ice-cooling, and the mixture was stirred at room temperature overnight. The resin was collected by filtration from the reaction mixture, washed twice with tetrahydrofuran-methanol (1:1) solution, three times with tetrahydrofuran, twice with methanol, once with piperidine, once with tetrahydrofuran and once with methanol in this order, and vacuum dried. To this resin was added 1 mol/L borane-tetrahydrofuran complex (25 ml) again, and the mixture was stirred at room temperature overnight. The resin was collected by filtration from the reaction mixture, washed once each with tetrahydrofuran, tetrahydrofuran-methanol (1:1) solution and tetrahydrofuran-piperidine (1:1) solution, then washed three times each with tetrahydrofuran and methanol, and vacuum dried to give the title pale-yellow resin (8.6 g).