1-Ethylpiperidin-3-one hydrochloride → HCID 19694168, Verbindung

HRID 915

Reaktionsgleichung

Reaktionsgleichung von HRID 915
[CH2:1]([N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[C:12]([Cl:17])[C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([N:20]1[CH2:25][CH2:24][CH2:23][C:22](=[O:26])[CH2:21]1)[CH3:19]>>[CH2:1]([N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[C:12]([Cl:17])[C:11]=2[N:10]=[C:9]1[C:22]1([OH:26])[CH2:23][CH2:24][CH2:25][N:20]([CH2:18][CH3:19])[CH2:21]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 4334391-Ethylpiperidin-3-one hydrochlorideHCID 141991521-Benzyl-4-chloro-1H-imidazo[4,5-c]pyridine

Produkt 1

HCID 19694168HCID 19694168, Verbindung

Versuchsvorschrift

Following the procedure of Example 13 and using 1-benzyl-4-chloro-1H-imidazo[4,5-c]pyridine (0.60 g, 2.5 mmol) and (0.36 g, 2.8 mmol) of N-ethyl-3-piperidone gave the free base of the title compound which was purified by flash chromatography on silica gel eluting with EtOAc to give, after preparation of the salt, the dihydrochloride, 0.59 hydrate as an amorphous solid, 0.30 g (26%):

Quellen und Nachweise

ORD-Eintrag
ord-ba5fcf5d0a3744acbef08bc1f8e5f3b4
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05723468

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