N-p-Bromophenylthiourea → N-[7-(4-Bromoanilino)-4,5-dihydro[1,3]thiazolo[4',5': 3,4]benzo[d][1,3]thiazol-2-yl]-N'-ethylurea

HRID 9153

Reaktionsgleichung

Br[CH:2]1[CH2:16][CH2:15][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])[S:8][C:4]=2[C:3]1=O.[Br:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH2:28])=[S:27])=[CH:21][CH:20]=1>C1COCC1>[Br:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26]2[S:27][C:2]3[CH2:16][CH2:15][C:5]4[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])[S:8][C:4]=4[C:3]=3[N:28]=2)=[CH:21][CH:20]=1

Komponenten

Reaktionsbedingungen

Temperatur: 65 °C

Versuchsvorschrift

A suspension of N-(6-bromo-7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)-N′-ethylurea (50 mg, 0.16 mmol) and 4-bromo-phenyl-thiourea (36 mg, 0.16 mmol) in THF (1.0 mL) was heated to about 65° C. for about 1.5 hrs. The reaction mixture was pumped down and used in the next step without further purification.

Aufarbeitung

customused in the next step without further purification

Quellen und Nachweise

ORD-Eintrag: ord-ea8233a5c256454ba3ea6ba2c519a36d
Quelldatensatz: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07091227B2

Verknüpfte Notizen

Wird geladen…