[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetic acid → 2-[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-ethanol
Reaktionsgleichung
[F:1][C:2]([F:25])([F:24])[CH2:3][N:4]1[C:8]([CH2:9][C:10](O)=[O:11])=[CH:7][C:6]([C:13]2[CH:18]=[CH:17][C:16]([O:19][C:20]([F:23])([F:22])[F:21])=[CH:15][CH:14]=2)=[N:5]1>O1CCCC1>[F:24][C:2]([F:1])([F:25])[CH2:3][N:4]1[C:8]([CH2:9][CH2:10][OH:11])=[CH:7][C:6]([C:13]2[CH:14]=[CH:15][C:16]([O:19][C:20]([F:23])([F:21])[F:22])=[CH:17][CH:18]=2)=[N:5]1Komponenten
3
Versuchsvorschrift
In analogy to the procedure described for example 9 c], [2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-acetic acid was reduced with a 1 M solution of BH3*THF in tetrahydrofuran to give 2-[2-(2,2,2-trifluoro-ethyl)-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-ethanol as colorless oil.