Triethylamine → N-benzoyl-N'-[3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]propyl]-sulfamide

HRID 915545Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 915545
[Cl:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[Cl:18])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13]N)[CH2:8][CH2:7]1.[CH2:19]([N:21](CC)CC)C.[C:26]([NH:34][S:35](Cl)(=[O:37])=[O:36])(=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>ClCCl>[C:26]([NH:34][S:35]([NH:21][CH2:19][CH2:13][CH2:12][N:9]1[CH2:8][CH2:7][CH:6]([O:5][C:4]2[CH:15]=[CH:16][C:17]([Cl:18])=[C:2]([Cl:1])[CH:3]=2)[CH2:11][CH2:10]1)(=[O:37])=[O:36])(=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 113582094-(3,4-Dichlorophenoxy)-1-piperidineethanamineHCID 11830956Benzoylsulfamoyl chloride

Produkt 1

HCID 69420940N-benzoyl-N'-[3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]propyl]-sulfamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4-(3,4-Dichlorophenoxy)-1-piperidineethanamine (0.16 g) was dissolved in dichloromethane (2 ml) and triethylamine (88 μl) was added. Benzoylsulfamoyl chloride (0.13 g) was added and the solution was stirred for 16 h. The solvent was evaporated and the residue was purified by HPLC (ammonium acetate: acetonitrile 95% to 5% aq) to give the title compound (6 mg).

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue was purified by HPLC (ammonium acetate: acetonitrile 95% to 5% aq)

Quellen und Nachweise

ORD-Eintrag
ord-ecc7985fd6f64511802911b351fe8c2a
Quelldatensatz
uspto-grants-2007_09
Patentnummer
US07265227B2

Notizen zur Reaktion

Wird geladen…