Benzyl methyl(piperidin-4-yl)carbamate hydrochloride → Benzyl 1-[4-(3-cyclohexyl-1-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-3-ethoxyphenyl]-4-piperidinyl(methyl)carbamate

HRID 915942Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 915942
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10](=[O:24])[C:11]3[C:16]([CH:17]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)=[N:15][N:14]([CH3:23])[C:12]=3[N:13]=2)=[C:4]([O:25][CH2:26][CH3:27])[CH:3]=1.Cl.[CH3:29][N:30]([CH:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)[C:31](=[O:40])[O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH:17]1([C:16]2[C:11]3[C:10](=[O:24])[NH:9][C:8]([C:5]4[CH:6]=[CH:7][C:2]([N:44]5[CH2:43][CH2:42][CH:41]([N:30]([CH3:29])[C:31](=[O:40])[O:32][CH2:33][C:34]6[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=6)[CH2:46][CH2:45]5)=[CH:3][C:4]=4[O:25][CH2:26][CH3:27])=[N:13][C:12]=3[N:14]([CH3:23])[N:15]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Komponenten

3

Edukt 2

HCID 18677745Benzyl methyl(piperidin-4-yl)carbamate hydrochlorideHCID 136005963HCID 136005963, Verbindung

Produkt 1

HCID 136333210Benzyl 1-[4-(3-cyclohexyl-1-methyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-3-ethoxyphenyl]-4-piperidinyl(methyl)carbamateAusbeute 77 %

Versuchsvorschrift

The same reaction procedure as in Example 27 was performed, except that the compound obtained in Example 85 was used in place of the compound obtained in Example 26, and benzyl methyl(4-piperidinyl)carbamate hydrochloride was used in place of N-methylpiperazine. In this manner, 234 mg (77%) of the captioned compound was obtained.

Aufarbeitung

  1. customThe same reaction procedure as in Example 27

Quellen und Nachweise

ORD-Eintrag
ord-0bfbadf1fe8b467f8152c5da47e8a2a7
Quelldatensatz
uspto-grants-2007_09
Patentnummer
US07268128B2

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