5-Bromo-2,3-dihydro-1-benzofuran → 4-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid ethyl ester

HRID 916017Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 916017
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.[CH2:11]([O:13][C:14](=[O:25])[C:15]([OH:24])([C:20]([F:23])([F:22])[F:21])[CH2:16][C:17]([CH3:19])=[CH2:18])[CH3:12].[Cl-].[Al+3].[Cl-].[Cl-]>C(=S)=S>[CH2:11]([O:13][C:14](=[O:25])[C:15]([OH:24])([C:20]([F:23])([F:22])[F:21])[CH2:16][C:17]([C:4]1[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=[C:2]([Br:1])[CH:3]=1)([CH3:19])[CH3:18])[CH3:12]

Komponenten

5

Edukt 3

HCID 27761595-Bromo-2,3-dihydro-1-benzofuranHCID 6451240Aluminum(III) ChlorideHCID 17935595Ethyl 2-hydroxy-4-methyl-2-(trifluoromethyl)pent-4-enoate

Produkt 1

HCID 589599534-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6348Carbon DisulfideLösungsmittel

Versuchsvorschrift

4-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid ethyl ester was prepared using the procedure described in Example 1 with 5-bromo-2,3-dihydrobenzofuran and 2-hydroxy-4-methyl-2-trifluoromethylpent-4-enoic acid ethyl ester in carbon disulfide with aluminum chloride.

Quellen und Nachweise

ORD-Eintrag
ord-3b1231a0b9f8450e974204fa1a0ea3e4
Quelldatensatz
uspto-grants-2007_09
Patentnummer
US07268152B2

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