4-{4-Amino-5-[3-(3,5-dichloro-benzenesulfonylamino)-benzoyl]-pyrrolo[2,3-d]pyrimidin-7-yl}-piperidine-1-carboxylic acid tert-butyl ester → N-[3-(4-Amino-7-piperidin-4-yl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-3,5-dichloro-benzenesulfonamide

HRID 916792

Reaktionsgleichung

Reaktionsgleichung von HRID 916792
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:18]3[N:19]=[CH:20][N:21]=[C:22]([NH2:23])[C:17]=3[C:16]([C:24](=[O:43])[C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([NH:31][S:32]([C:35]4[CH:40]=[C:39]([Cl:41])[CH:38]=[C:37]([Cl:42])[CH:36]=4)(=[O:34])=[O:33])[CH:26]=3)=[CH:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.NC1C2C(C(C3C=C(NC(NC4C=C(Cl)C=C(Cl)C=4)=O)C=CC=3)=O)=CN(C3CCNCC3)C=2N=CN=1>>[NH2:23][C:22]1[C:17]2[C:16]([C:24]([C:25]3[CH:26]=[C:27]([NH:31][S:32]([C:35]4[CH:40]=[C:39]([Cl:41])[CH:38]=[C:37]([Cl:42])[CH:36]=4)(=[O:34])=[O:33])[CH:28]=[CH:29][CH:30]=3)=[O:43])=[CH:15][N:14]([CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[C:18]=2[N:19]=[CH:20][N:21]=1

Komponenten

3

Edukt 2

HCID 672193824-{4-Amino-5-[3-(3,5-dichloro-benzenesulfonylamino)-benzoyl]-pyrrolo[2,3-d]pyrimidin-7-yl}-piperidine-1-carboxylic acid tert-butyl esterHCID 672198621-[3-(4-Amino-7-piperidin-4-yl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-3-(3,5-dichloro-phenyl)-urea

Produkt 1

HCID 67219958N-[3-(4-Amino-7-piperidin-4-yl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-3,5-dichloro-benzenesulfonamide

Versuchsvorschrift

The title compound was prepared from 4-{4-Amino-5-[3-(3,5-dichloro-benzenesulfonylamino)-benzoyl]-pyrrolo[2,3-d]pyrimidin-7-yl}-piperidine-1-carboxylic acid tert-butyl ester by procedures analogous to those described for the preparation of 1-[3-(4-Amino-7-piperidin-4-yl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-3-(3,5-dichloro-phenyl)-urea. MS: 546.5 (MH+); HPLC Rf: 4.91 min. (HPLC method 4); HPLC purity: 100%.

Quellen und Nachweise

ORD-Eintrag
ord-b57441af525d4b78927d1d9cec7cec97
Quelldatensatz
uspto-grants-2007_09
Patentnummer
US07271262B2

Verknüpfte Notizen

Wird geladen…