Losartan → Losartan magnesium

HRID 917005

Reaktionsgleichung

Reaktionsgleichung von HRID 917005
[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[N:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:22]=3[C:23]3[N:27]=[N:26][NH:25][N:24]=3)=[CH:15][CH:16]=2)[C:8]([CH2:28][OH:29])=[C:7]([Cl:30])[N:6]=1.[O-]CC.[Mg+2:34].[O-]CC.CCCCCCC>C(O)(C)C>[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:22]=3[C:23]3[N:27]=[N:26][NH:25][N:24]=3)=[CH:13][CH:12]=2)[C:8]([CH2:28][OH:29])=[C:7]([Cl:30])[N:6]=1.[Mg:34]

Komponenten

5

Edukt 3

HCID 3961LosartanHCID 8900HeptaneHCID 164963Magnesium ethanolate

Produkt 1

HCID 69163106Losartan magnesiumAusbeute 159,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

To 40.81 g of losartan of Example 1 in 235 ml of i-propanol, 6.07 g magnesium ethoxide were added, and stirred at reflux temperature overnight. Reaction mixture was hot filtered, 650 ml n-heptane were added, and cooled to room temperature for the product to precipitate. It was filtered and washed with 110 ml n-heptane, and dried in vacuo at 50° C. to yield 37.9 g losartan magnesium.

Aufarbeitung

  1. temperatureat reflux temperature overnight
  2. customReaction mixture
  3. additionwere added
  4. customto precipitate
  5. filtrationIt was filtered
  6. washwashed with 110 ml n-heptane
  7. customdried in vacuo at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-a5358b6b1572448ea4d2dcdec3a5f674
Quelldatensatz
uspto-grants-2007_09
Patentnummer
US07271269B2

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