Propyl chloroformate → Propyl 4-(aminomethyl)-2-chloro-6-methylphenylcarbamate

Reaktionsgleichung

C([NH:4][C:5]1[C:12]([CH3:13])=[CH:11][C:8]([CH2:9][NH2:10])=[CH:7][C:6]=1[Cl:14])(=O)C.Cl[C:16]([O:18][CH2:19][CH2:20][CH3:21])=[O:17]>>[NH2:10][CH2:9][C:8]1[CH:11]=[C:12]([CH3:13])[C:5]([NH:4][C:16](=[O:17])[O:18][CH2:19][CH2:20][CH3:21])=[C:6]([Cl:14])[CH:7]=1

Komponenten

Edukt 2

HCID 7998Propyl chloroformate

HCID 58962953N-[4-(Aminomethyl)-2-chloro-6-methylphenyl]acetamide

Produkt 1

HCID 58962959Propyl 4-(aminomethyl)-2-chloro-6-methylphenylcarbamate

Versuchsvorschrift

The procedure is exactly the same as preparing 4-acetamido-3-chloro-5-methylbenzylamine (Preparation D), except that propyl chloroformate was used instead of acetyl chloride.

Quellen und Nachweise

ORD-Eintrag: ord-11f3735b8b804e5a81264c11a57ce557
Quelldatensatz: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07273882B2

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