HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,3-Cyclohexanedione → 2-Amino-4-(4,6-dimethoxypyrimid-5-yl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,3-Cyclohexanedione | HCID 10434 | — |
| Edukt | 4,6-Dimethoxypyrimidine-5-carbaldehyde | HCID 4436645 | — |
| Edukt | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 2-Amino-4-(4,6-dimethoxypyrimid-5-yl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester | HCID 70635082 | 65% |
Reaktionsschritte
Upon boiling a solution of 5.7 g of 4,6-dimethoxypyrimidin-5-aldehyde, 3.8 g of cyclohexane-1,3-dione and 4.4 g of amidinoacetic acid ethyl ester in 80 ml of ethanol for 8 hours, 2-amino-4-(4,6-dimethoxypyrimid-5-yl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester of melting point 273°C (alcohol) is obtained. Yield: 65% of theory.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US03971791 |
| Quelldatensatz | uspto-grants-1976_07 |
| ORD ID | ord-d45147eab6e84b88947ea5008576f5c5 |
| Quellennotiz | uspto-grants-1976_07 |