Ethanol → Ethyl 3-benzylamino-5-sulphamyl-4-(m-trifluoromethylphenoxy)-benzoate
Reaktionsgleichung
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([S:22](=[O:25])(=[O:24])[NH2:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=1)[C:5]([OH:7])=[O:6].[CH2:26](Br)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.[CH2:34](O)[CH3:35]>>[CH2:26]([NH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([S:22](=[O:24])(=[O:25])[NH2:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:19])([F:21])[F:20])[CH:13]=1)[C:5]([O:7][CH2:34][CH3:35])=[O:6])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1Komponenten
4
Versuchsvorschrift
A mixture of 3-amino-5-sulphamyl-4-(m-trifluoromethylphenoxy)-benzoic acid (1.82 g), benzyl bromide (2 g), and anhydrous ethanol (15 ml) was refluxed for 7 hours. The soluton was cooled, and the precipitated ethyl 3-benzylamino-5-sulphamyl-4-(m-trifluoromethylphenoxy)-benzoate was collected by suction. After recrystallization from ethanol, the melting pont was 166°-168°C.