4-bromo-1-methyl-1H-pyrazole-5-carbaldehyde → 1-[4'-(5-Formyl-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

HRID 919090Notizen

Reaktionsgleichung

Br[C:2]1[CH:6]=[N:5][N:4]([CH3:7])[C:3]=1[CH:8]=[O:9].[CH2:10]([O:12][C:13]([C:15]1([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27](B4OC(C)(C)C(C)(C)O4)=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)[CH2:17][CH2:16]1)=[O:14])[CH3:11]>>[CH2:10]([O:12][C:13]([C:15]1([C:18]2[CH:19]=[CH:20][C:21]([C:24]3[CH:25]=[CH:26][C:27]([C:2]4[CH:6]=[N:5][N:4]([CH3:7])[C:3]=4[CH:8]=[O:9])=[CH:28][CH:29]=3)=[CH:22][CH:23]=2)[CH2:17][CH2:16]1)=[O:14])[CH3:11]

Komponenten

Edukt 2

HCID 27946344-bromo-1-methyl-1H-pyrazole-5-carbaldehyde

HCID 679580391-[4'-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

Produkt 1

HCID 866970901-[4'-(5-Formyl-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

Versuchsvorschrift

Prepared according to the procedure described in Example 5, Step 2, using the following starting materials: 4-bromo-2-methyl-2H-pyrazole-3-carbaldehyde and 1-[4′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester.

Aufarbeitung

customPrepared

Quellen und Nachweise

ORD-Eintrag: ord-fcd26976bf2b4d53b1ce6672ec367a33
Quelldatensatz: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09272990B2

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