Ethyl diazoacetate → HCID 90177064, Verbindung

HRID 919309Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 919309
[CH:1]([C:3]1[CH:12]=[CH:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N:4]=1)=[CH2:2].[N+](=[CH:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N-]>C1(C)C=CC=CC=1>[N:4]1[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=[CH:12][C:3]=1[CH:1]1[CH2:2][CH:15]1[C:16]([O:18][CH2:19][CH3:20])=[O:17]

Komponenten

4

Edukt 2

HCID 12192Ethyl diazoacetateHCID 22935206HCID 22935206, Verbindung

Produkt 1

HCID 90177064HCID 90177064, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of 2 (1.6 g, 10 mmol) in toluene (50 ml) was treated with ethyl diazoacetate (1.7 g, 15 mmol) and stirred at reflux overnight. The mixture was concentrated and the residue was purified by gradient elution on silica gel (0 to 10% EtOAc in hexanes) to afford the title compound as a pale yellow oil. LRMS m/z (M+H) 246.2 found, 246.2 required.

Aufarbeitung

  1. temperatureat reflux overnight
  2. concentrationThe mixture was concentrated
  3. customthe residue was purified by gradient elution on silica gel (0 to 10% EtOAc in hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-17ff61d70c34477b905a9fae1e64a74a
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09273033B2

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