2,3-Difluorobenzylamine → 8-(2,3-Difluoro-benzylamino)-1-methyl-1,2,3,4-tetrahydro-pyrimido[1,6-a]pyrimidin-6-one
Reaktionsgleichung
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][NH2:10].Cl[C:12]1[CH:22]=[C:16]2[N:17]([CH3:21])[CH2:18][CH2:19][CH2:20][N:15]2[C:14](=[O:23])[N:13]=1>>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][NH:10][C:12]1[CH:22]=[C:16]2[N:17]([CH3:21])[CH2:18][CH2:19][CH2:20][N:15]2[C:14](=[O:23])[N:13]=1Komponenten
3
Versuchsvorschrift
The title compound or its salt was prepared by a procedure similar to that described for E59 starting from (2,3-difluorophenyl)methanamine and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.
Quellen und Nachweise
- ORD-Eintrag
- ord-ad3c4e8de46845c2a1b47d50cc3cb0a2
- Quelldatensatz
- uspto-grants-2016_03