Hydrochloric Acid → HCID 86683146, Verbindung

HRID 920932Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 920932
[N:1]1[C:2]([CH2:10][CH2:11][N:12]2[C:21](=[O:22])[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][C:19]=3[NH:23][C@@H:24]3[CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25]3)[CH:14]=[N:13]2)=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.[ClH:36].C(OC(C)C)(C)C>C(Cl)Cl.C(O)(C)C>[ClH:36].[ClH:36].[N:1]1[C:2]([CH2:10][CH2:11][N:12]2[N:13]=[CH:14][C:15]3[C:20](=[C:19]([NH:23][C@@H:24]4[CH2:28][CH2:27][NH:26][CH2:25]4)[CH:18]=[CH:17][CH:16]=3)[C:21]2=[O:22])=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl Ether2×HCID 86683144HCID 86683144, Verbindung

Produkt 1

HCID 86683146HCID 86683146, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3776IsopropanolLösungsmittel2×HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of (R)-tert-butyl 3-(3-(2-(imidazo[1,2-a]pyridin-2-yl)ethyl)-4-oxo-3,4-dihydrophthalazin-5-ylamino)pyrrolidine-1-carboxylate from Example 218 (52 mg, 0.110 mmol) in 20 mL of DCM was mixed with 1 mL of HCl containing isopropanol and the reaction mixture was stirred under nitrogen for 12 h at room temperature. The reaction mixture was mixed with diisopropyl ether and the supernatant was discharged. Then, the residue was dissolved in isopropanol and diisopropyl ether was added. The supernatant was discharged. The precipitate was dried to give 24 mg of a yellow salt as solid foam. LC-MS: m/e=357.2 (M+H)+

Aufarbeitung

  1. customThe precipitate was dried

Quellen und Nachweise

ORD-Eintrag
ord-9a7eb7f8014f4d34b7aade20e8ee7388
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09273068B2

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