Potassium Carbonate → Methanone,4-morpholinyl[5,6,7,8-tetrahydro-3-(trifluoromethyl)imidazo[1,5-a]pyrazin-1-yl]-

HRID 920981Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 920981
Cl.[O:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[N:11]=[C:12]([C:19]([F:22])([F:21])[F:20])[N:13]3[CH2:18][CH2:17][NH:16][CH2:15][C:14]=23)=[O:9])[CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+]>C(OCC)(=O)C>[O:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[N:11]=[C:12]([C:19]([F:21])([F:22])[F:20])[N:13]3[CH2:18][CH2:17][NH:16][CH2:15][C:14]=23)=[O:9])[CH2:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 86685646Morpholino-[3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl]methanone hydrochloride

Produkt 1

HCID 68011886Methanone,4-morpholinyl[5,6,7,8-tetrahydro-3-(trifluoromethyl)imidazo[1,5-a]pyrazin-1-yl]-Ausbeute 98,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Crude morpholino-[3-(trifluoromethyl)-5,6,7,8-tetrahydro imidazo[1,5-a]pyrazin-1-yl]methanone hydrochloride 20c (330 mg, 1 mmol) was dissolved in 10 mL of ethyl acetate, followed by addition of potassium carbonate (10 g, 72 mmol). After stirring for 4 hours, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure to obtain crude morpholino-[3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-1-yl]methanone 20d (300 mg) as a light yellow solid. The product was used directly in the next reaction without purification.

Aufarbeitung

  1. filtrationthe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-32aa5e5429c9438195581fc1a175171b
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09273052B2

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