Potassium Carbonate → N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide

HRID 920994Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 920994
Cl.[CH:2]1([CH2:5][NH:6][C:7]([C:9]2[N:10]=[C:11]([C:18]([F:21])([F:20])[F:19])[N:12]3[CH2:17][CH2:16][NH:15][CH2:14][C:13]=23)=[O:8])[CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+]>ClCCl>[CH:2]1([CH2:5][NH:6][C:7]([C:9]2[N:10]=[C:11]([C:18]([F:19])([F:20])[F:21])[N:12]3[CH2:17][CH2:16][NH:15][CH2:14][C:13]=23)=[O:8])[CH2:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 86685650N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro imidazo[1,5-a]pyrazine-1-carboxamide hydrochloride

Produkt 1

HCID 68011901N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamideAusbeute 112,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide hydrochloride 24b (250 mg, 0.77 mmol) was dissolved in 10 mL of dichloromethane, followed by addition of potassium carbonate (320 mg, 2.30 mmol). After stirring for 4 hours, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure to obtain crude N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide 24c (250 mg) as a yellow solid. The product was used directly in the next reaction without purification.

Aufarbeitung

  1. filtrationthe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9cfd8df8bd854eabaaa57d9e669a35d5
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09273052B2

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