Methanamine, N-methoxy-, hydrochloride (1:1) → 1-(5-Bromo-6-methoxypyridin-3-yl)ethan-1-one

HRID 922425Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 922425
[Br:1][C:2]1[C:3]([O:11][CH3:12])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.Cl.[CH3:14]NOC.C[Mg]Br>>[Br:1][C:2]1[CH:10]=[C:6]([C:7](=[O:9])[CH3:14])[CH:5]=[N:4][C:3]=1[O:11][CH3:12]

Komponenten

4

Edukt 3

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 457904665-Bromo-6-methoxy-3-pyridinecarboxylic acidHCID 178418573HCID 178418573, Verbindung

Produkt 1

HCID 838940271-(5-Bromo-6-methoxypyridin-3-yl)ethan-1-one

Versuchsvorschrift

5-Bromo-6-methoxynicotinic acid and N,O-dimethylhydroxylamine hydrochloride were treated in the similar manner to Reference Example 7(5), and then the resulting compound and methylmagnesium bromide were treated in the similar manner to Reference Example 7(6) to give 1-(5-bromo-6-methoxypyridin-3-yl)ethanone [Ex(296-1)] as a colorless powder.

Quellen und Nachweise

ORD-Eintrag
ord-df787c6a77c74c04923310bf2b837528
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09278944B2

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