hydrogen chloride CPME → N-(4-{trans-2-[(cyclopropylmethyl)amino]cyclopropyl}phenyl)-2-fluoro-5-(trifluoromethyl)benzamide hydrochloride

HRID 922536Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 922536
C(OC(=O)[N:7]([CH2:31][CH:32]1[CH2:34][CH2:33]1)[C@@H:8]1[CH2:10][C@H:9]1[C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:30])[C:19]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:20]=2[F:29])=[CH:13][CH:12]=1)(C)(C)C.[ClH:36].COC1CCCC1>C1COCC1>[ClH:36].[CH:32]1([CH2:31][NH:7][C@@H:8]2[CH2:10][C@H:9]2[C:11]2[CH:12]=[CH:13][C:14]([NH:17][C:18](=[O:30])[C:19]3[CH:24]=[C:23]([C:25]([F:27])([F:28])[F:26])[CH:22]=[CH:21][C:20]=3[F:29])=[CH:15][CH:16]=2)[CH2:33][CH2:34]1

Komponenten

4

Edukt 2

HCID 66926893hydrogen chloride CPMEHCID 86729899Tert-butyl (cyclopropylmethyl)[trans-2-(4-{[2-fluoro-5-(trifluoromethyl)benzoyl]amino}phenyl)-cyclopropyl]carbamate

Produkt 1

HCID 86729897N-(4-{trans-2-[(cyclopropylmethyl)amino]cyclopropyl}phenyl)-2-fluoro-5-(trifluoromethyl)benzamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of tert-butyl(cyclopropylmethyl)[trans-2-(4-{[2-fluoro-5-(trifluoromethyl)benzoyl]amino}phenyl)-cyclopropyl]carbamate (110 mg) in THF (1 mL) was ice-cooled, and 4N hydrochloric acid/cyclopentyl methyl ether solution (15 mL) was added. The mixture was stirred at room temperature overnight and the solvent was evaporated under reduced pressure. The residue was recrystallized from methanol/diisopropyl ether to give the title compound (72.0 mg).

Aufarbeitung

  1. temperaturecooled
  2. customthe solvent was evaporated under reduced pressure
  3. customThe residue was recrystallized from methanol/diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-33591c72013241d09654f301c70a87f5
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09278931B2

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