hydrogen chloride CPME → N-(4-{trans-2-[(2-phenylpiperidin-4-yl)amino]cyclopropyl}phenyl)-3-(trifluoromethyl)benzamide dihydrochloride
Reaktionsgleichung
[C:1]1([CH:7]2[CH2:12][CH:11]([NH:13][C@@H:14]3[CH2:16][C@H:15]3[C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:35])[C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=4)=[CH:19][CH:18]=3)[CH2:10][CH2:9][N:8]2C(OC(C)(C)C)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:43].COC1CCCC1>C1COCC1>[ClH:43].[ClH:43].[C:1]1([CH:7]2[CH2:12][CH:11]([NH:13][C@@H:14]3[CH2:16][C@H:15]3[C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:35])[C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:32])([F:33])[F:34])[CH:26]=4)=[CH:19][CH:18]=3)[CH2:10][CH2:9][NH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
tert-Butyl 2-phenyl-4-{[trans-2-(4-{[3-(trifluoromethyl)benzoyl]amino}phenyl)cyclopropyl]amino}-piperidine-1-carboxylate (62 mg) was dissolved in THF (0.5 mL), and the mixture was ice-cooled to 0° C. 4N Hydrochloric acid/cyclopentyl methyl ether solution (5.0 mL) was added, and the mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure. The residue was recrystallized from methanol/diisopropyl ether to give the title compound (24 mg).
Aufarbeitung
- customThe solvent was evaporated under reduced pressure
- customThe residue was recrystallized from methanol/diisopropyl ether
Quellen und Nachweise
- ORD-Eintrag
- ord-b25bf44b8300471eb1fb2b2cbc70396c
- Quelldatensatz
- uspto-grants-2016_03
- Patentnummer
- US09278931B2
Notizen zur Reaktion
Wird geladen…