hydrogen chloride CPME → 2-(4-{trans-2-[(cyclopropylmethyl)amino]cyclopropyl}phenyl)-1H-isoindole-1,3(2H)-dione hydrochloride

HRID 922551Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 922551
C(OC(=O)[N:7]([CH2:28][CH:29]1[CH2:31][CH2:30]1)[C@@H:8]1[CH2:10][C@H:9]1[C:11]1[CH:16]=[CH:15][C:14]([N:17]2[C:25](=[O:26])[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:18]2=[O:27])=[CH:13][CH:12]=1)(C)(C)C.[ClH:33].COC1CCCC1>>[ClH:33].[CH:29]1([CH2:28][NH:7][C@@H:8]2[CH2:10][C@H:9]2[C:11]2[CH:16]=[CH:15][C:14]([N:17]3[C:18](=[O:27])[C:19]4[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=4)[C:25]3=[O:26])=[CH:13][CH:12]=2)[CH2:30][CH2:31]1

Komponenten

3

Edukt 2

HCID 66926893hydrogen chloride CPMEHCID 86729920tert-butyl(cyclopropylmethyl){trans-2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]cyclopropyl}carbamate

Produkt 1

HCID 867299212-(4-{trans-2-[(cyclopropylmethyl)amino]cyclopropyl}phenyl)-1H-isoindole-1,3(2H)-dione hydrochloride

Versuchsvorschrift

tert-Butyl(cyclopropylmethyl){trans-2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]cyclopropyl}carbamate (252.7 mg) was dissolved in 4N hydrochloric acid/cyclopentyl methyl ether solution (3 mL), and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure. The residue was recrystallized from methanol/diisopropyl ether to give the title compound (176.2 mg).

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from methanol/diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-f48775da472249bd92e3eba12862015f
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09278931B2

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