(S)-(-)-N-Boc-prolinol → HCID 58984973, Verbindung

Reaktionsgleichung

[C:1]([O:5][C:6]([N:8]1[CH2:14][C@@H:13]([O:15][CH3:16])[CH2:12][C@H:9]1[CH2:10][OH:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC(N1CCC[C@H]1CO)=O)(C)(C)C>>[C:1]([O:5][C:6]([N:8]1[CH2:14][C@@H:13]([O:15][CH3:16])[CH2:12][C@H:9]1[CH:10]=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

Edukt 2

HCID 643448(S)-(-)-N-Boc-prolinol

HCID 589850231,1-Dimethylethyl (2S,4S)-2-(hydroxymethyl)-4-methoxy-1-pyrrolidinecarboxylate

Produkt 1

HCID 58984973HCID 58984973, Verbindung

Versuchsvorschrift

With the exception that N-t-butoxycarbonyl-cis-4-methoxy-L-prolinol, instead of N-t-butoxycarbonyl-L-prolinol, was used, the same procedure as in Preparation Example 1-1 was repeated to afford the title compound. 6.94 g (65%).

Aufarbeitung

customthe same procedure as in Preparation Example 1-1

Quellen und Nachweise

ORD-Eintrag: ord-a8efbec2b944404d93bc2a6fc174b1ba
Quelldatensatz: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09278996B2

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