Hydrochloric Acid → (3S,4S)-4-Aminopyrrolidin-3-ol dihydrochloride

HRID 924123Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 924123
[NH2:1][C@@H:2]1[C@@H:6]([OH:7])[CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.CCO.[ClH:18]>>[ClH:18].[ClH:18].[NH2:1][C@H:2]1[CH2:3][NH:4][CH2:5][C@@H:6]1[OH:7]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 104654571-Boc-(3S,4S)-3-amino-4-hydroxypyrrolidine

Produkt 1

HCID 69959682(3S,4S)-4-Aminopyrrolidin-3-ol dihydrochloride

Versuchsvorschrift

(3S,4S)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate (0.3 g, 1.439 mmol) in 1.25 M HCl 1.25 M in EtOH (11.51 mL, 14.39 mmol) was stirred for 24 h at RT. The white suspension was evaporated to dryness under reduced pressure and the residue was suspended in MeOH (10 mL) and evaporated again to afford the title compound.

Aufarbeitung

  1. customThe white suspension was evaporated to dryness under reduced pressure
  2. customevaporated again

Quellen und Nachweise

ORD-Eintrag
ord-f55e85da7c6f42ddb636bea58c38c01a
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09278981B2

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