Potassium Hydroxide → 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid

HRID 924624

Reaktionsgleichung

Reaktionsgleichung von HRID 924624
[CH2:1]([O:3][C:4](=[O:13])[C:5]([CH3:12])([CH3:11])[C:6]([O:8]CC)=[O:7])[CH3:2].[OH-].[K+]>C(O)C>[CH2:1]([O:3][C:4](=[O:13])[C:5]([CH3:12])([CH3:11])[C:6]([OH:8])=[O:7])[CH3:2]

Komponenten

4

Edukt 2

HCID 14797Potassium Hydroxide2×HCID 15382Diethyl dimethylmalonate

Produkt 1

HCID 2317543-Ethoxy-2,2-dimethyl-3-oxopropanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

25 g 2,2-Dimethyl-malonic acid diethyl ester, 7.8 g potassium hydroxide and 500 ml ethanol were mixed in a round-bottomed flask and refluxed for 3 hours. Then again 2.2 g potassium hydroxide were added and the mixture was refluxed overnight. The solvent was removed on a rotovap, 250 ml H2O were added and the mixture was washed with ether. The aqueous phase was acidified with HCl to pH 3-4 followed by two extractions with dichloromethane. The organic solvent was dried and evaporated and the resulting product was characterized by 1H-NMR.

Aufarbeitung

  1. temperaturerefluxed for 3 hours
  2. temperaturethe mixture was refluxed overnight
  3. customThe solvent was removed on a rotovap, 250 ml H2O
  4. additionwere added
  5. washthe mixture was washed with ether
  6. extractionfollowed by two extractions with dichloromethane
  7. customThe organic solvent was dried
  8. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-d05ddce2c4654619837edad593ea50d2
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09283186B2

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