Iodine → Ethanone, 1-(4-amino-3-iodophenyl)-

HRID 925329Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 925329
[I:1]I.[NH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:12])[CH3:11])=[CH:6][CH:5]=1>C(O)C.S([O-])([O-])(=O)=O.[Ag+2]>[NH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:12])[CH3:11])=[CH:6][C:5]=1[I:1]

Komponenten

5

Edukt 2

HCID 807IodineHCID 7468p-Aminoacetophenone

Produkt 1

HCID 11032652Ethanone, 1-(4-amino-3-iodophenyl)-Ausbeute 18 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418844HCID 178418844, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

1-(4-amino-3-iodophenyl)ethanone was prepared according to method D Step I with Iodine (2.82 g; 11.10 mmol) silver sulphate (3.46 g; 11.10 mmol) and 1-(4-aminophenyl)ethanone (1.50 g; 11.10 mmol) in ethanol (40 mL). The crude residue was purified by flash chromatography on silica gel (eluent 2 to 40% ethyl acetate in heptane) to yield 0.514 g (18%) of 1-(4-amino-3-iodophenyl)ethanone as a pale yellow solid.

Aufarbeitung

  1. custom1-(4-amino-3-iodophenyl)ethanone was prepared
  2. customThe crude residue was purified by flash chromatography on silica gel (eluent 2 to 40% ethyl acetate in heptane)

Quellen und Nachweise

ORD-Eintrag
ord-fd36ce67307a4bc6ba1e7af89729e803
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09284271B2

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