Ammonia methanol → 5-Bromo-3-methylpyridine-2-carboxamide

Reaktionsgleichung

C([O:3][C:4]([C:6]1[C:11]([CH3:12])=[CH:10][C:9]([Br:13])=[CH:8][N:7]=1)=O)C.[NH3:14].CO>>[Br:13][C:9]1[CH:10]=[C:11]([CH3:12])[C:6]([C:4]([NH2:14])=[O:3])=[N:7][CH:8]=1

Komponenten

Edukt 2

HCID 21705897Ammonia methanol

HCID 53418426Ethyl 5-bromo-3-methylpicolinate

Produkt 1

HCID 685225135-Bromo-3-methylpyridine-2-carboxamide

Versuchsvorschrift

5-Bromo-3-methyl-pyridine-2-carboxylic acid ethyl ester (2.44 g, 10 mmol) was dissolved in NH3/MeOH (50 ml) and heated to reflux for 3 days. The reaction mixture was concentrated to give the desired product as a pink solid (2.05 g, 9.6 mmol).

Aufarbeitung

temperatureheated
temperatureto reflux for 3 days
concentrationThe reaction mixture was concentrated

Quellen und Nachweise

ORD-Eintrag: ord-ec17b29b8ff54250b0977df129b33a17
Quelldatensatz: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09284284B2

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