Ethyl orthoformate → HCID 178518012, Verbindung

Reaktionsgleichung

[NH2:1][C:2]1[C:3]([C:12]([NH2:14])=[O:13])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH2:15](OC(OCC)OCC)C>>[F:10][C:8]([F:11])([F:9])[C:6]1[CH:5]=[N:4][C:3]2[C:12]([OH:13])=[N:14][CH:15]=[N:1][C:2]=2[CH:7]=1

Komponenten

Edukt 2

HCID 31214Ethyl orthoformate

HCID 867281563-Amino-5-(trifluoromethyl)picolinamide

Produkt 1

HCID 178518012HCID 178518012, Verbindung

Reaktionsbedingungen

Temperatur: 120 °C

Versuchsvorschrift

A mixture of 3-amino-5-trifluoromethyl-pyridine-2-carboxylic acid amide (500 mg, 2.44 mmol) and triethoxymethane (1.8 g, 12.2 mmol) were heated to 120° C. for 16 h. The mixture was cooled to ambient temperature and treated with low boiling PE. The reaction mixture was stirred for 10 minutes, cooled to 0° C. and the beige solid was collected by filtration (350 mg).

Aufarbeitung

temperatureThe mixture was cooled to ambient temperature
additiontreated with low boiling PE
temperaturecooled to 0° C.
filtrationthe beige solid was collected by filtration (350 mg)

Quellen und Nachweise

ORD-Eintrag: ord-95c61101f97141a385c08a694088815e
Quelldatensatz: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09284284B2

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