HCID 59484893, Verbindung → 6-(5-methyloxazol-2-yl)-2H-pyridazin-3-one

HRID 925476Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 925476
[CH2:1]([NH:4][C:5]([C:7]1[CH:12]=[CH:11][C:10](=[O:13])[NH:9][N:8]=1)=[O:6])[C:2]#[CH:3]>C(#N)C.[Au](Cl)(Cl)Cl>[CH3:3][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][C:10](=[O:13])[NH:9][N:8]=2)=[N:4][CH:1]=1

Komponenten

4

Edukt 1

HCID 59484893HCID 59484893, Verbindung

Produkt 1

HCID 594849556-(5-methyloxazol-2-yl)-2H-pyridazin-3-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 26030Gold trichlorideKatalysator2×HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

622 mg (2.05 mmol) of gold(III) chloride are added to a solution of 3.69 g (20.5 mmol) of N-prop-2-ynyl-6-oxo-1,6-dihydropyridazine-3-carboxamide in 41 ml of acetonitrile, and the mixture is stirred at room temperature for 3 days. A further 622 mg (2.05 mmol) of gold(III) chloride are added, and the mixture is stirred at room temperature for 7 days. The reaction mixture is evaporated and chromatographed on a silica gel column with dichloromethane/methanol as eluent: 6-(5-methyloxazol-2-yl)-2H-pyridazin-3-one as yellowish crystals; ESI 178.

Aufarbeitung

  1. stirringthe mixture is stirred at room temperature for 7 days
  2. customThe reaction mixture is evaporated
  3. customchromatographed on a silica gel column with dichloromethane/methanol as eluent

Quellen und Nachweise

ORD-Eintrag
ord-4204fdd97dd0496fb8244425c4a9950d
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09284300B2

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