Hydrochloric Acid → 8-(4-Hydroxy-phenyl)-1-propyl-1,7-dihydro-purin-6-one

HRID 925539Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 925539
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16](COCC[Si](C)(C)C)[C:15]3[C:14](=[O:25])[N:13]([CH2:26][CH2:27][CH3:28])[CH:12]=[N:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.Cl>C(O)C>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:16][C:15]3[C:14](=[O:25])[N:13]([CH2:26][CH2:27][CH3:28])[CH:12]=[N:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 1363910238-(4-Hydroxy-phenyl)-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one

Produkt 1

HCID 1363910248-(4-Hydroxy-phenyl)-1-propyl-1,7-dihydro-purin-6-oneAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

A mixture of 8-(4-hydroxy-phenyl)-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one (0.03 g, 0.075 mmol), 2N HCl (1 ml), ethanol (2 ml) was heated at 85° C. for 2 hours. The mixture was cooled and the solvent was evaporated. The residue was washed with n-pentane to obtain 8-(4-Hydroxy-phenyl)-1-propyl-1,7-dihydro-purin-6-one (0.019 g, 95%) as a yellow solid.

Aufarbeitung

  1. temperatureThe mixture was cooled
  2. customthe solvent was evaporated
  3. washThe residue was washed with n-pentane

Quellen und Nachweise

ORD-Eintrag
ord-4e599a5a7cfe47cc8b0789a6ea8b335c
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09284316B2

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