1-methyl-1H-pyrrole-3-carboxylic acid → [1-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-1H-pyrrol-3-yl](pyrrolidin-1-yl)methanone

HRID 925630Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 925630
[CH:1]1([N:5]2[CH2:10][CH2:9][CH:8]([O:11][C:12]3[CH:17]=[CH:16][C:15](I)=[CH:14][CH:13]=3)[CH2:7][CH2:6]2)[CH2:4][CH2:3]C1.IC1C=CC(OCCCN2CCC[C@H]2C)=CC=1.CN1C=CC(C(O)=O)=C1.[N:45]1([C:50]([C:52]2[CH:56]=[CH:55][NH:54][CH:53]=2)=[O:51])[CH2:49][CH2:48][CH2:47][CH2:46]1>>[CH3:9][C@@H:10]1[CH2:3][CH2:4][CH2:1][N:5]1[CH2:6][CH2:7][CH2:8][O:11][C:12]1[CH:13]=[CH:14][C:15]([N:54]2[CH:55]=[CH:56][C:52]([C:50]([N:45]3[CH2:49][CH2:48][CH2:47][CH2:46]3)=[O:51])=[CH:53]2)=[CH:16][CH:17]=1

Komponenten

5

Edukt 4

HCID 101540541-methyl-1H-pyrrole-3-carboxylic acidHCID 158517393-(pyrrolidin-1-ylcarbonyl)-1H-pyrroleHCID 57675747(2R)-1-[3-(4-iodophenoxy)propyl]-2-methylpyrrolidineHCID 675486081-Cyclobutyl-4-(4-iodophenoxy)piperidine

Produkt 1

HCID 117640920[1-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]propoxy}phenyl)-1H-pyrrol-3-yl](pyrrolidin-1-yl)methanone

Versuchsvorschrift

The titled compound was prepared as a colorless amorphous substance by repeating the procedure of Example 1, except that the 1-cyclobutyl-4-(4-iodophenoxy)piperidine was replaced by (2R)-1-[3-(4-iodophenoxy)propyl]-2-methylpyrrolidine (which can be synthesized in accordance with the method described in WO2009063953) and the methyl 1H-pyrrole-3-carboxylic acid by 3-(pyrrolidin-1-ylcarbonyl)-1H-pyrrole.

Aufarbeitung

  1. customcan be synthesized in accordance with the method

Quellen und Nachweise

ORD-Eintrag
ord-0dc2bfb247904b69b401d99b5c5642dc
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09284324B2

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