Reaktionsgleichung
C[O:2][C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH3:20][O:21][CH3:22]>>[C:3]([OH:19])(=[O:2])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH3:20][O:21][CH3:22]Komponenten
Reaktionsbedingungen
- Temperatur
- 65 °C
Versuchsvorschrift
Palmitic acid methyl ester (2.00 g; 7.40 mmol) was combined with poly(ethylene glycol) (PEG-12) monomethyl ether 550 (4.41 g; 7.40 mmol; 1.0 equiv) having an average molecular weight of 596 (available from Sigma-Aldrich Chemical Company) in a 40-milliliter vial equipped with a magnetic stir bar. Immobilized Candida antarctica lipase B immobilized on a porous fluoropolymer support as described in US published Patent Application 2012/0040395 was added to the flask in an amount of 0.13 grams, (2 wt % based on the total weight of starting materials). The mixture was stirred and heated to 65° C. and purged with a subsurface stream of nitrogen at a rate of 100 mL/min. After 24 hours a final sample was removed and analyzed by GC to determine conversion of methyl palmitate to palmitic acid methyl ester ethoxylate. Conversion was as follows: after 3 hours, 64.8%; after 6 hours, 80.8%, after 12 hours, 92.1%; and after 23 hours, 96.4%.
Aufarbeitung
- customvial equipped with a magnetic stir bar
- additionwas added to the flask in an amount of 0.13 grams
- custompurged with a subsurface stream of nitrogen at a rate of 100 mL/min
- customAfter 24 hours a final sample was removed
- waitafter 6 hours
- wait80.8%, after 12 hours
- waitand after 23 hours
Quellen und Nachweise
- ORD-Eintrag
- ord-b364cf90193c4827a39d61ad3a177e25
- Quelldatensatz
- uspto-grants-2016_03
- Patentnummer
- US09284583B2
Verknüpfte Notizen
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