(1-Methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanol → (1-Methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanone

HRID 926501

Reaktionsgleichung

Reaktionsgleichung von HRID 926501
[CH3:1][N:2]1[C:6]([CH:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[OH:8])=[CH:5][N:4]=[CH:3]1>O1CCOCC1.[O-2].[O-2].[Mn+4]>[CH3:1][N:2]1[C:6]([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[O:8])=[CH:5][N:4]=[CH:3]1

Komponenten

4

Edukt 1

HCID 86715604(1-Methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanol

Produkt 1

HCID 86715605(1-Methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A heterogenous mixture of (1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanol (1.41 g, 7.45 mmol, Intermediate 33: step a) and manganese dioxide (3.24 g, 37.27 mmol) in 1,4-dioxane (52 mL) was stirred at 100° C. for 2 hours. The reaction mixture was then cooled to room temperature, filtered through Celite®, washed with DCM, and concentrated to provide the title compound as an off-white solid.

Aufarbeitung

  1. filtrationfiltered through Celite®
  2. washwashed with DCM
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-b311ad1dec01437892ff3059d79c7e1d
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09284308B2

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