1H-1,2,4-Triazole → 5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

HRID 926734

Reaktionsgleichung

Reaktionsgleichung von HRID 926734
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[NH:11]1[CH:15]=[N:14][CH:13]=[N:12]1.C([O-])([O-])=O.[K+].[K+]>>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH:15]=[N:14][CH:13]=[N:12]2)=[N:3][CH:4]=1)([O-:10])=[O:9]

Komponenten

4

Edukt 3

HCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 952642-Fluoro-5-nitropyridine

Produkt 1

HCID 27667645-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

2-fluoro-5-nitropyridine (30 g, 18.9 mmol) was added to a stirred solution of 1H-1,2,4-triazole (1.566 g, 22.7 mmol) and K2CO3 (5.14 g, 37.8 mmol) and stirred for 16 hrs at 25° C. Reaction mass was diluted with ice cold water and stirred for 15 min. The solid obtained was filtered and dried under vacuum to afford the desired product. MS (ESI): m/z 192 (M+H).

Aufarbeitung

  1. customReaction mass
  2. additionwas diluted with ice cold water
  3. stirringstirred for 15 min
  4. customThe solid obtained
  5. filtrationwas filtered
  6. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-d12b4aebdc51445c9bea7eac74105a05
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09289419B2

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