Potassium Hydroxide → Amantadine

HRID 926901

Reaktionsgleichung

Reaktionsgleichung von HRID 926901
Cl.[C:2]12([NH2:12])[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([CH2:5]3)[CH2:3]1)[CH2:9]2.[OH-].[K+]>>[C:2]12([NH2:12])[CH2:9][CH:8]3[CH2:7][CH:6]([CH2:5][CH:4]([CH2:10]3)[CH2:3]1)[CH2:11]2

Komponenten

3

Edukt 2

HCID 14797Potassium HydroxideHCID 64150Amantadine Hydrochloride

Produkt 1

HCID 2130Amantadine

Versuchsvorschrift

An aqueous solution of 1-adamantylamine hydrochloride (Alfa-Aesar, 99%) was treated with potassium hydroxide and extracted with toluene, dried over Na2SO4, filtered and stripped down by rotary evaporation to give 30.3 g 1-adamantylamine (200 mmol). The procedure for compound 1, above, was followed except the reaction was heated at 45° C. overnight yielding 26.23 g white solids (62.8 mmol, 63% yield). When performing the activated carbon treatment 2:1 water/absolute ethanol was used to dissolve the residue.

Aufarbeitung

  1. extractionextracted with toluene
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. customstripped down by rotary evaporation

Quellen und Nachweise

ORD-Eintrag
ord-2a96ff9932fe44e98afecd7913bfb30a
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09289757B2

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