Ethyl Acetate → HCID 178424566, Verbindung

HRID 927143

Reaktionsgleichung

Reaktionsgleichung von HRID 927143
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28]([C:39]#[C:40][C:41]2[CH:46]=[CH:45][C:44]([F:47])=[C:43]([CH3:48])[CH:42]=2)=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1.C(OCC)(=O)C>CO>[F:47][C:44]1[CH:45]=[CH:46][C:41]([CH2:40][CH2:39][C:28]2[CH:29]=[C:30]([OH:31])[C:25](=[O:24])[NH:26][N:27]=2)=[CH:42][C:43]=1[CH3:48]

Komponenten

5

Edukt 3

HCID 8857Ethyl AcetateHCID 712703693,4-Bis(benzyloxy)-6-[2-(4-fluoro-3-methylphenyl)ethynyl]pyridazine2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Produkt 1

HCID 178424566HCID 178424566, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[2-(4-fluoro-3-methylphenyl)ethynyl]pyridazine (Intermediate 29) except that the solvent mixture used for the hydrogenation was made up of ethyl acetate and methanol (1:1) and the final material was recrystallised from ethyl acetate.

Aufarbeitung

  1. customthe final material was recrystallised from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-2b934151f75d4befb6839552acdcb1c9
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09290456B2

Verknüpfte Notizen

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