1,1-Dimethoxyethyl(dimethyl)amine → HCID 86674739, Verbindung

HRID 927374Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 927374
[NH2:1][C:2](=[S:14])[C:3]([NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:5])[CH3:4].CO[C:17](OC)([N:19]([CH3:21])[CH3:20])[CH3:18]>C(Cl)Cl>[C:9]([O:8][C:7](=[O:13])[NH:6][C:3]([CH3:5])([CH3:4])[C:2]([N:1]=[C:17]([N:19]([CH3:21])[CH3:20])[CH3:18])=[S:14])([CH3:12])([CH3:11])[CH3:10]

Komponenten

4

Edukt 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 15186362tert-butyl N-(1-carbamothioyl-1-methylethyl)carbamate

Produkt 1

HCID 86674739HCID 86674739, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of tert-butyl 1-amino-2-methyl-1-thioxopropan-2-ylcarbamate (Example 12 b, 0.218 g, 1 mmol) and 1,1-dimethoxy-N,N-dimethylethanamine (CAN 18871-66-4, 0.16 g, 1.2 mmol) in methylene chloride (10 mL) was stirred at room temperature for 24 h. Then it was concentrated to give crude product, which was used directly in the next step without further purification (0.28 g, 98%) as yellow oil; MS (EI): m/e 288.2 [M+H]+.

Aufarbeitung

  1. concentrationThen it was concentrated
  2. customto give crude product, which
  3. customwas used directly in the next step without further purification (0.28 g, 98%) as yellow oil

Quellen und Nachweise

ORD-Eintrag
ord-9340c697d82d41e6a0819b1612966716
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09290451B2

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