Hydrochloric Acid → 5-Methyl-6-sulfo-pyridine-2-carboxylic acid methyl ester

HRID 927385Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 927385
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([OH:14])=[O:13])=[N:6][C:7]=1[S:8]([OH:11])(=[O:10])=[O:9].Cl.[CH3:16]O>O1CCOCC1>[CH3:16][O:13][C:12]([C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[C:7]([S:8]([OH:11])(=[O:9])=[O:10])[N:6]=1)=[O:14]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 866747445-Methyl-6-sulfo-pyridine-2-carboxylic acid

Produkt 1

HCID 866747455-Methyl-6-sulfo-pyridine-2-carboxylic acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a mixture of 5-methyl-6-sulfo-pyridine-2-carboxylic acid (0.8 g, 3.69 mmol) in methanol (20 mL) was added 4 N hydrogen chloride in dioxane (8 mL). The mixture was stirred overnight at room temperature. Undissolved solid was filtered off, and the filtrate was concentrated to give the product as yellow solid 0.5 g; MS (EI): m/e=232.0 [M+H]+.

Aufarbeitung

  1. filtrationwas filtered off
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-cd1771dfcdf04cd49d0935621885f1a7
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09290451B2

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