(S)-alpha-amino-cyclopropanepropanamide → 5-Bromo-6-cyclopropylmethoxy-pyridine-2-carboxylic acid ((S)-1-carbamoyl-2-cyclopropyl-ethyl)-amide
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:13]([OH:15])=O)=[N:6][C:7]=1[O:8][CH2:9][CH:10]1[CH2:12][CH2:11]1.[NH2:16][C@@H:17]([CH2:21][CH:22]1[CH2:24][CH2:23]1)[C:18]([NH2:20])=[O:19]>>[C:18]([C@@H:17]([NH:16][C:13]([C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[C:7]([O:8][CH2:9][CH:10]2[CH2:11][CH2:12]2)[N:6]=1)=[O:15])[CH2:21][CH:22]1[CH2:24][CH2:23]1)(=[O:19])[NH2:20]Komponenten
3
Versuchsvorschrift
The title compound was synthesized in analogy to Example 1, using 5-bromo-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 9 d) and (S)-2-amino-3-cyclopropyl-propionamide (CAN 156077-93-9) as starting materials, MS (EI): m/e=382.0 [M+H]+.
Quellen und Nachweise
- ORD-Eintrag
- ord-7e0fa0d83608452fa22b113f22a46841
- Quelldatensatz
- uspto-grants-2016_03
- Patentnummer
- US09290451B2
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