6-((Tetrahydro-2H-pyran-4-yl)methoxy)-5-(trifluoromethyl)picolinic acid → 2-Ethyl-2-{[6-(tetrahydro-pyran-4-ylmethoxy)-5-trifluoromethyl-pyridine-2-carbonyl]-amino}-butyric acid methyl ester

HRID 927680

Reaktionsgleichung

Reaktionsgleichung von HRID 927680
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][O:8][C:9]2[N:14]=[C:13]([C:15]([OH:17])=O)[CH:12]=[CH:11][C:10]=2[C:18]([F:21])([F:20])[F:19])[CH2:3][CH2:2]1.Cl.[NH2:23][C:24]([CH2:31][CH3:32])([CH2:29][CH3:30])[C:25]([O:27][CH3:28])=[O:26]>>[CH3:28][O:27][C:25](=[O:26])[C:24]([CH2:31][CH3:32])([NH:23][C:15]([C:13]1[CH:12]=[CH:11][C:10]([C:18]([F:21])([F:20])[F:19])=[C:9]([O:8][CH2:7][CH:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)[N:14]=1)=[O:17])[CH2:29][CH3:30]

Komponenten

3

Edukt 2

HCID 710873886-((Tetrahydro-2H-pyran-4-yl)methoxy)-5-(trifluoromethyl)picolinic acidHCID 75488114Methyl 2-amino-2-ethylbutanoate hydrochloride

Produkt 1

HCID 710874152-Ethyl-2-{[6-(tetrahydro-pyran-4-ylmethoxy)-5-trifluoromethyl-pyridine-2-carbonyl]-amino}-butyric acid methyl ester

Versuchsvorschrift

The title compound was synthesized in analogy to Example 1, using 6-((tetrahydro-2H-pyran-4-yl)methoxy)-5-(trifluoromethyl)picolinic acid (Example 230 b) and methyl 2-amino-2-ethylbutanoate hydrochloride (CAN 92398-54-4) as starting materials, MS (EI): m/e=433.5 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-a93922aa8bb64dbca8454aad24eb3edc
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09290451B2

Verknüpfte Notizen

Wird geladen…