Ethyl 2-amino-2-ethylbutanoate hydrochloride → 2-[(5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid ethyl ester

HRID 927702

Reaktionsgleichung

Reaktionsgleichung von HRID 927702
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][C:20]([CH2:28][CH3:29])([CH2:26][CH3:27])[C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[CH2:24]([O:23][C:21](=[O:22])[C:20]([NH:19][C:15]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([CH2:28][CH3:29])[CH2:26][CH3:27])[CH3:25]

Komponenten

3

Edukt 2

HCID 24201639Ethyl 2-amino-2-ethylbutanoate hydrochlorideHCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Produkt 1

HCID 710879382-[(5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid ethyl ester

Versuchsvorschrift

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42 a) and ethyl 2-amino-2-ethylbutanoate hydrochloride (CAN 1135219-29-2) as starting materials. MS (EI): m/e=375.0 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-2d16d40c35bc4676bf4782c745bd811d
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09290451B2

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