Ethyl formate → N-(4-dimethylaminobutyl)formamide

Reaktionsgleichung

[CH3:1][N:2]([CH3:8])[CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[CH:9](OCC)=[O:10]>>[CH3:1][N:2]([CH3:8])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][CH:9]=[O:10]

Komponenten

Edukt 2

HCID 8025Ethyl formate

HCID 770634-Dimethylaminobutylamine

Produkt 1

HCID 54572491N-(4-dimethylaminobutyl)formamide

Versuchsvorschrift

A solution of 4-dimethylaminobutylamine (3.0 g) in ethyl formate (30 mL) was stirred and heated at reflux under an atmosphere of nitrogen for 3 hours. After cooling, the mixture was evaporated to dryness and the residue was purified by chromatography on silica, eluting with a mixture of methanol and DCM (20%) to give N-(4-dimethylaminobutyl)formamide (2.7 g) as a pale yellow oil.

Aufarbeitung

temperatureheated
temperatureat reflux under an atmosphere of nitrogen for 3 hours
temperatureAfter cooling
customthe mixture was evaporated to dryness
customthe residue was purified by chromatography on silica
washeluting with a mixture of methanol and DCM (20%)

Quellen und Nachweise

ORD-Eintrag: ord-80c57ad9e6fd47408c1b2686fd0f3111
Quelldatensatz: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09290472B2

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