Trifluoroacetic acid → (S)-Benzyl pyrrolidine-3-carboxylate trifluoroacetic acid salt

HRID 928054Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 928054
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC([N:15]1[CH2:19][CH2:18][C@H:17]([C:20]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:21])[CH2:16]1)=O)(C)(C)C>C(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:15]1[CH2:19][CH2:18][C@H:17]([C:20]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:21])[CH2:16]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 59016658benzyl (S)-1-tert-butoxycarbonylpyrrolidine-3-carboxylate2×

Produkt 1

HCID 86713356(S)-Benzyl pyrrolidine-3-carboxylate trifluoroacetic acid salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Trifluoroacetic acid (2.5 mL) was added to a solution of benzyl (S)-1-tert-butoxycarbonylpyrrolidine-3-carboxylate (Intermediate 192, 0.859 g) and DCM (10 mL) at room tempertaure. The mixture was stirred for 4 hours then concentrated in vacuo. The residue was azetroped with toluene then ethyl acetate to give benzyl (S)-pyrrolidine-3-carboxylate trifluoroacetic acid salt (1 g).

Aufarbeitung

  1. concentrationthen concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a1c1a47808554c9194699f24778aea35
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09290472B2

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