2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI) → (S,E)-4-(8-Amino-3-(1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI)	HCID 14805664	—
Edukt	(S)-4-(8-Amino-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide	HCID 71226368	—
Produkt	(S,E)-4-(8-Amino-3-(1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide	HCID 71226385	46,6%

Reaktionsschritte

This compound was prepared, in an analogous manner as described in Example 2, from the compound described in intermediate 2b and (E)-4-(dimethylamino)but-2-enoic acid, to afford the title compound (11.8 mg, 46.6%). Data: UPLC (C) Rt: 1.29 min; m/z 511.0 (M+H)+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09290504B2
Quelldatensatz	uspto-grants-2016_03
ORD ID	ord-3b92e5ecd9f94c1092a334c31c50b4b4
Quellennotiz	uspto-grants-2016_03