4-Propylpyridin-2-amine → 2-fluoro-N-(4-propylpyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

HRID 928337Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 928337
FC1C=CN=C(NC(=O)C2C=CC(B3OC(C)(C)C(C)(C)O3)=CC=2)C=1.[F:26][C:27]1[CH:35]=[C:34]([B:36]2[O:40][C:39]([CH3:42])([CH3:41])[C:38]([CH3:44])([CH3:43])[O:37]2)[CH:33]=[CH:32][C:28]=1[C:29]([OH:31])=O.[CH2:45]([C:48]1[CH:53]=[CH:52][N:51]=[C:50]([NH2:54])[CH:49]=1)[CH2:46][CH3:47]>>[F:26][C:27]1[CH:35]=[C:34]([B:36]2[O:40][C:39]([CH3:42])([CH3:41])[C:38]([CH3:44])([CH3:43])[O:37]2)[CH:33]=[CH:32][C:28]=1[C:29]([NH:54][C:50]1[CH:49]=[C:48]([CH2:45][CH2:46][CH3:47])[CH:53]=[CH:52][N:51]=1)=[O:31]

Komponenten

4

Edukt 3

HCID 70225944-Propylpyridin-2-amineHCID 447176654-Carboxy-3-fluorobenzeneboronic acid pinacol esterHCID 71222688N-(4-fluoropyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

Produkt 1

HCID 712231942-fluoro-N-(4-propylpyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamideAusbeute 63,3 %

Versuchsvorschrift

This compound was prepared, in an analogous manner as described in Intermediate 4, starting from commercially available 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid and 4-propyl-pyridin-2-ylamine, to afford the title compound (830 mg, 63.3%).

Aufarbeitung

  1. customThis compound was prepared, in an analogous manner

Quellen und Nachweise

ORD-Eintrag
ord-1a2d0a1923ff4ca4bfa71377ad4eb48b
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09290504B2

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